Outras investigações, que fizeram repetidas radiografias ao longo do tempo também, descobriram que o excesso de peso aumenta significativamente o risco de desenvolver OA nos joelhos. Estima-se que as pessoas no quintil mais alto do peso corporal têm até 10 vezes o risco aumentado de desenvolver OA nos joelhos do que aqueles no quintil mais baixo. Mesmo pequenas quantidades de perda de peso, reduzem o risco de desenvolvimento de OA nos joelhos. Estudos preliminares sugerem que a perda de peso diminui a dor substancialmente naqueles com OA nos joelhos.
Dr. João Santos Caio Jr.
Endocrinologia – Neuroendocrinologista
CRM 20611
Dra. Henriqueta V. Caio
Endocrinologista – Medicina Interna
CRM 28930
1. Condições normais e patológicas têm um impacto imediato sobre as funções cerebrais...
http://hormoniocrescimentoadultos.blogspot.com.
2. Além disso, os neurônios e células gliais existem em uma relação de estrutura funcional mútua apertada que é altamente dependente do fornecimento periférico da fonte de energia principalmente de glicose às células...
http://longevidadefutura.blogspot.com
3. Provas convergentes indicam que a insulina desempenha várias funções críticas do SNC sob condições normais e anormais...
http://imcobesidade.blogspot.com
AUTORIZADO O USO DOS DIREITOS AUTORAIS COM CITAÇÃO
DOS AUTORES PROSPECTIVOS ET REFERÊNCIA BIBLIOGRÁFICA.
Referências Bibliográficas:
Caio Jr, João Santos, Dr.; Endocrinologista, Neuroendocrinologista, Caio,H. V., Dra. Endocrinologista, Medicina Interna – Van Der Häägen Brazil, São Paulo, Brasil; World Health Organization: Obesity and overweight; Anandacoomarasamy A, Fransen M, March L. Obesity and the musculoskeletal system. Curr Opin Rheumatol. 2009;21:71–7; Brooks PM. Impact of osteoarthritis on individuals and society: how much disability? Social consequences and health economic implications. Curr Opin Rheumatol. 2002;14:573–7; Anandacoomarasamy A, Caterson I, Sambrook P, Fransen M, March L. The impact of obesity on the musculoskeletal system. Int J Obes (Lond) 2008; 32:211–22; Spector TD, Hart DJ, Doyle DV. Incidence and progression of osteoarthritis in women with unilateral knee disease in the general population: the effect of obesity. Ann Rheum Dis. 1994;53:565–8; Szoeke C, Dennerstein L, Guthrie J, Clark M, Cicuttini F. The relationship between prospectively assessed body weight and physical activity and prevalence of radiological knee osteoarthritis in postmenopausal women. J Rheumatol. 2006;33:1835–40; Coggon D, Reading I, Croft P, McLaren M, Barrett D, Cooper C. Knee osteoarthritis and obesity. Int J Obes Relat Metab Disord. 2001;25:622–7; Blagojevic M, Jinks C, Jeffery A, Jordan KP. Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis. Osteoarthritis Cartilage. 2010; 18:24–33; Anandacoomarasamy A, Leibman S, Smith G, Caterson I, Giuffre B, Fransen M, et al. Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage. Ann Rheum Dis. 2012; 71:26–32; Jiang L, Rong J, Wang Y, Hu F, Bao C, Li X, et al. The relationship between body mass index and hip osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2011;78:150–5; Jiang L, Tian W, Wang Y, Rong J, Bao C, Liu Y, et al. Body mass index and susceptibility to knee osteoarthritis: a systematic review and meta-analysis. Joint Bone Spine. 2012;79:291–7; Holliday KL, McWilliams DF, Maciewicz RA, Muir KR, Zhang W, Doherty M. Lifetime body mass index, other anthropometric measures of obesity and risk of knee or hip osteoarthritis in the GOAL case-control study. Osteoarthritis Cartilage. 2011;19:37–43; M, Pols HA, Bergink AP, Hazes JM, Belo JN, Lievense AM, et al. Body mass index associated with onset and progression of osteoarthritis of the knee but not of the hip: the Rotterdam Study. Ann Rheum Dis. 2007; 66:158–62; Brandt KD, Mazzuca SA. Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. (xi-xii).Rheum Dis Clin North Am. 2006;32:217–34; Liu B, Balkwill A, Banks E, Cooper C, Green J, Beral V. Relationship of height, weight and body mass index to the risk of hip and knee replacements in middle-aged women. Rheumatology (Oxford )2007;46:861–7.
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